Immune system and Corona virus
- Posted By
10Pointer
- Categories
Science & Technology
- Published
7th May, 2021
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Context
Scientists have come up with the most complete picture yet is coming into focus of how the antibodies work to neutralize the part of the virus which is responsible for causing infection.
About the key findings
- The research was conducted at the University of Texas at Austin (UTexas) and published in the journal Science.
- Previous research: It focused on one group of antibodies that targeted the most obvious part of the coronavirus’s spike protein, which is called the receptor-binding domain (RBD).
- The RBD is the part of the spike that attaches directly to human cells and enables the virus to infect them.
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Receptor-binding domain (RBD)
- It is a key part of a virus that is located on its ‘spike’ domain which allows it to dock to body receptors to gain entry into cells and lead to infection.
- These are also the primary targets in the prevention and treatment of viral infections.
- It is a short immunogenic fragment of a virus that binds to a specific endogenous receptor sequence to gain entry into host cells.
- It is referred to a part of the ‘spike’ glycoprotein (S-domain) which is needed to interact with endogenous receptors to facilitate membrane fusion and delivery to the cytoplasm.
- Typically, the S-domain is also the site of neutralizing antibodies.
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- It was assumed to be a primary target of the immune system.
- New finding: The researchers found that most of the antibodies circulating in the blood — on average, about 84% — target areas of the viral spike protein outside the RBD.
- These antibodies are painting the entire spike, both the arc and the stalk of the spike protein, which looks a bit like an umbrella.
- The immune system sees the entire spike and tries to neutralise it.
- Many of these non-RBD-directed antibodies act as a potent weapon against the virus by targeting a region in a part of the spike protein located in what would be the umbrella’s canopy called the N-terminal domain (NTD).
- The NTD is also a part of the viral spike protein that mutates frequently, especially in several variants of concern.
- The N-terminus is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
- This suggests that one reason these variants are so effective at evading our immune systems is that they can mutate around one of the most common and potent types of antibody in our arsenals.
